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本文对河北省27个县市区、117个自然村的440人献血员进行丙型肝炎病毒(HCV)感染及其影响因素的分析,发现献血员丙型肝炎病毒抗体(抗-HCV)阳性率为27.0％,无献血史成人为5.2％,相对危险性(RR)为5.19,归因危险度(AR)为80.7％。单采浆还输血球献血员和全血献血员抗-HCV 阳性率分别为41.1％和14.6％,RR 分别为7.90和2.81,AR 分别为87.3％和64.4％。通过非条件 Logistic 回归分析,献血员 HCV 感染率高低与性别、血站类型、血清谷丙转氨酶(ALT)异常和 ALT 异常史有关,而与年龄、献血次数和年限无明显关系,但在单因素分析中,献血次数与抗-HCV 阳性率呈正相关关系。我们还发现,有ALT 异常史的献血员抗-HCV 阳性率高达55.6％,血站通过 ALT 筛检并不能剔除这类人群,这是造成我国输血后丙型肝炎的重要原因。
In this paper, 440 blood donors from 117 villages in 27 counties of Hebei Province were investigated for hepatitis C virus (HCV) infection and its influencing factors. The positive rate of anti-HCV in blood donors was 27.0%, and 5.2% of adults without blood donation. The relative risk (RR) was 5.19 and the attributable risk (AR) was 80.7%. The positive rates of anti-HCV in monophasized blood transfused blood donors and whole blood donors were 41.1% and 14.6%, respectively, with RRs of 7.90 and 2.81, respectively, with ARs of 87.3% and 64.4%, respectively. Non-conditional Logistic regression analysis showed that the prevalence of HCV infection in blood donors was related to gender, type of bloodstain, abnormal ALT and history of ALT, but not to age, frequency of donation and age. However, Analysis, the number of blood donations and anti-HCV positive rate was positively correlated. We also found that anti-HCV positive rate of blood donors with a history of abnormal ALT was as high as 55.6%. Blood tests by ALT can not exclude such people, which is the main reason for hepatitis C after blood transfusion in China.