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目的 探讨低温液体(4℃)静脉灌注对家兔局灶性脑缺血的保护作用。方法 30只家兔制成大脑中动脉梗死模型后,随机分成3组:对照组(Ⅰ组)、体表降温组(Ⅱ组)和低温液体(4℃)静脉灌注组(Ⅲ组),脑温(Tc)降至(34.5±0.5)℃,维持24 h,并检测颅内压(ICP)、脑灌注压(CPP)和中心静脉压(CVP)等指标。结果 两低温组脑温降至35℃用时分别为(48.0±7.1)min(Ⅱ组)和(52.3±8.9)min(Ⅲ组),两组间无显著性差异(P>0.05);亚低温期,Ⅲ组ICP从(12.5±2.2)mmHg降至(11.0±2.2)mmHg(12 h)和(10.5±2.0)mmHg(24 h),CPP从(75.9±6.2)mmHg上升至(86.3±7.3)mmHg(2 h)、(81.9±3.9)mmHg(12 h)和(80.9±5.1)mmHg(24 h),与对照组比较,两低温组ICP降低,CPP升高(P<0.05),同时Ⅲ组CPP显著高于Ⅱ组(P<0.05)。结论 低温液体(4℃)静脉灌注能降低脑温和颅内压,并提高脑灌注压,对缺血性脑损伤有明显的保护作用,是一种安全有效的治疗方法。
Objective To investigate the protective effect of intravenous infusion of cryogenic liquid (4 ℃) on focal cerebral ischemia in rabbits. Methods Thirty rabbits were randomly divided into three groups: control group (group Ⅰ), body cooling group (group Ⅱ) and hypothermia liquid (group Ⅳ) intravenous infusion (group Ⅲ), brain The temperature (Tc) dropped to (34.5 ± 0.5) ℃ for 24 h. ICP, CPP and CVP were measured. Results The temperature of the hypothermia group was (48.0 ± 7.1) min (group Ⅱ) and (52.3 ± 8.9) min (group Ⅲ), respectively, with no significant difference between the two groups (P> 0.05) The ICP decreased from (12.5 ± 2.2) mmHg to (11.0 ± 2.2) mmHg (12 h) and (10.5 ± 2.0) mmHg (24 h) in group Ⅲ, and CPP increased from (75.9 ± 6.2) mmHg to (86.3 ± 7.3) (P <0.05), ICP (P <0.05), and ICP (P <0.05) in the two hypothermia groups compared with the control group The CPP in group Ⅲ was significantly higher than that in group Ⅱ (P <0.05). Conclusion Intravenous perfusion with cryogenic fluid (4 ℃) can decrease cerebral temperature and intracranial pressure and increase cerebral perfusion pressure, which has a significant protective effect on ischemic brain injury. It is a safe and effective treatment.