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目的 探讨高危新生儿正中神经体感诱发电位 (MNSEP)的变化及临床意义。方法 对 36例高危新生儿及 30例正常新生儿进行MNSEP测试 ,其中的 30例高危儿在生后 6个月及 1岁时除进行MNSEP测试外 ,并对其进行体格检查和智力评估。结果 ①高危新生儿组的中枢神经传导时间 (CCT)明显长于正常新生儿 (P<0 0 5 ) ,两组间周围神经传导时间 (PCT)无明显差异 (P >0 0 5 ) ;30例正常新生儿全部引出皮层波N2 0 ,36例高危儿 5 8侧引出N2 0波 ,余 14侧缺失。②对 30例高危儿进行半年及 1年神经系统检查 ,3次MNSEP测试结果均正常者 8例 ,其智力及体格发育均正常 ;3次MNSEP持续异常者 7例 ,均留有不同程度神经系统后遗症。结论 高危新生儿MNSEP异常主要表现为CCT延长或皮层波N2 0缺失或二者兼有之 ,MNSEP对高危新生儿病情监测及预后判断有一定的价值
Objective To investigate the changes and clinical significance of MNSEP in high-risk neonates. Methods Thirty-six high-risk neonates and 30 normal neonates were tested for MNSEP. Thirty high-risk infants were divided into MNSEP at 6 months and 1 year after birth, and their physical examination and intelligence assessment were performed. Results ① The CCT in high-risk neonates was significantly longer than that in normal neonates (P <0.05), and there was no significant difference in peripheral nerve conduction time (PCT) between the two groups (P> 0.05) Normal neonates all lead to cortical waves N2 0, 36 cases of high-risk children on the 58 side of N2 0 waves, the remaining 14 missing. ② 30 cases of high-risk children for half a year and 1 year neurological examination, three MNSEP test results were normal in 8 cases, their mental and physical development were normal; 3 cases of MNSEP persistent abnormalities in 7 cases, were left with varying degrees of nervous system Sequelae. Conclusions The abnormalities of MNSEP in high-risk neonates are mainly manifested by prolongation of CCT or loss of N2 0 in cortex wave or both, and MNSEP has some value in monitoring and prognosis of high-risk neonates