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目的:了解环磷酰胺及其5种代谢物在骨髓移植病人中的药动学特点,并确定给予环磷酸胺1～2d后血浆中4-羟基环磷酰胺药时曲线下面积(AUC)增大的机制。 方法:给18例病人静注环磷酰胺(在1h内注射,600mg·kg~(-1),qd),连续2d。使第1天和第2天环磷酰胺及4-羟基环磷酰胺的药时数据符合为了估计4-羟基环磷酰胺的
OBJECTIVE: To understand the pharmacokinetics of cyclophosphamide and its five metabolites in patients with bone marrow transplantation and to determine the area under the curve (AUC) of plasma 4-hydroxycyclophosphamide after 1 to 2 days of administration of cyclophosphamide Big mechanism. Methods: 18 patients were given intravenous cyclophosphamide (injected within 1 h, 600 mg · kg -1, qd) for 2 days. Drug data for cyclophosphamide and 4-hydroxycyclophosphamide on Day 1 and Day 2 were matched in order to estimate the 4-hydroxycyclophosphamide