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全身性红斑狼疮(SLE)最有用的实验诊断,是证实血循环中存在抗天然双链的DNA抗体,但这种试验需要特殊放射性或免疫荧光的设备,不但费时而价值昂贵。SLE的主要特征是抗核因子(ANF),在SLE患者中ANF的发生可在95％以上,它具有IgG组的特征,虽可通过大白鼠肝基质进行间接免疫荧光试验得到证明,但特异性不高,对许多与之无关的疾病包括肝脏自身免疫性疾病、胶原性紊乱以及应用某些治疗药物的副作用等情况下,亦可检出ANF因子而造成诊断上的不准确。
The most useful experimental diagnosis of systemic lupus erythematosus (SLE) is to confirm the presence of anti-natural double-stranded DNA antibodies in the blood circulation, but this test requires special radioactive or immunofluorescence equipment that is both time-consuming and expensive. The primary feature of SLE is anti-nuclear factor (ANF), which occurs more than 95% in SLE patients and has the characteristics of the IgG group, although demonstrated by indirect immunofluorescence in rat liver stroma, but specificity Not high, the diagnosis of inaccurate ANF factors can also be detected in a number of unrelated diseases, including autoimmune liver disease, collagen disorders and the side effects of certain therapeutic agents.