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目的:探讨膀胱炎性肌纤维母细胞瘤(IMTUB)的临床诊断及治疗。方法:回顾性分析我院病理检查确诊为IMTUB的5例患者临床资料:5例术前均诊断为膀胱肿瘤,临床表现均缺乏特异性。光镜下可见梭形或长梭形细胞增生,且呈囊状分布,伴有间质小血管增生及大量浆细胞、嗜酸性粒细胞、中性粒细胞及淋巴细胞浸润。免疫表型上,间变性淋巴瘤激酶阳性5例,Desmin阳性4例,3例行膀胱部分切除术,2例行经尿道膀胱肿瘤电切术。结果:5例均临床治愈。随访11~63个月,平均34个月,患者无明显的血尿及尿频、尿急等症状,B超检查未见肿物复发。结论:IMTUB是一种交界性并具恶性潜能的肿瘤,临床诊断困难,确诊依赖于病理组织学及免疫组织化学染色检查。治疗以手术为主。
Objective: To investigate the clinical diagnosis and treatment of bladder inflammatory myofibroblastoma (IMTUB). Methods: The clinical data of 5 patients diagnosed IMTUB by pathology in our hospital were retrospectively analyzed: 5 cases were all diagnosed as bladder tumor preoperatively, and their clinical manifestations were lack of specificity. Under the light microscope, spindle-shaped or spindle-shaped cells were observed with cystic distribution accompanied by interstitial small vessel hyperplasia and a large number of plasma cells, eosinophils, neutrophils and lymphocytes infiltration. Immunophenotype, anaplastic lymphoma kinase-positive in 5 cases, Desmin-positive in 4 cases, 3 cases of partial partial resection of the bladder, 2 cases of transurethral resection of the bladder tumor. Results: All the 5 cases were cured. All patients were followed up for 11 to 63 months with an average of 34 months. No obvious hematuria, frequent urination, urgency and other symptoms were found in the patients. No recurrence was found in the B-ultrasound. Conclusion: IMTUB is a borderline and malignant tumor with difficult clinical diagnosis. The diagnosis depends on histopathology and immunohistochemical staining. The main treatment is surgery.