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FK506是具有强大免疫抑制作用的大环内酯类抗生素，现正用于器官移植和自体免疫性疾病的临床试验。FK506主要通过‘抑制IL－2的mRNA转录而发挥免疫抑制作用。FK506与环状多肽的CyA结构不同而作用相同，对它在T淋巴细胞活化与抑制机理中的作用研究已取得较大进展。现已在细胞中
FK506 is a macrolide antibiotic with a strong immunosuppressive effect and is currently being used in clinical trials of organ transplantation and autoimmune diseases. FK506 mainly acts as an immunosuppressive agent by inhibiting the transcription of IL-2 mRNA. FK506 has the same function as CyA of cyclic polypeptide, and has made great progress in its role in the mechanism of T lymphocyte activation and inhibition. Now in the cell