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目的:观察中药“创伤膏”对化疗药物渗漏局部皮肤组织损伤的治疗作用。方法:通过检测肿胀消退指数、瘀斑发生率、瘢痕脱离率以及病理切片等,研究中药“创伤膏”对大鼠背部皮下注射盐酸阿霉素所造成的化疗药物渗漏局部皮肤组织损伤模型的治疗作用。结果:与对照组相比,中药“创伤膏”作用于化疗药物渗漏局部皮肤组织损伤模型后,大鼠背部皮损浅红、轻度水肿、溃疡较小,且肿胀消退时间较短,瘀斑发生率低而瘢痕脱落率较高,病理组织显示弥散性炎细胞浸润,表皮完好。结论:中药“创伤膏”对化疗药物渗漏局部皮肤组织损伤具有较好的治疗作用。
Objective: To observe the therapeutic effect of traditional Chinese medicine “trauma cream” on local dermal tissue damage induced by chemotherapy drugs. Methods: The effects of traditional Chinese medicine “trauma cream” on the subcutaneous injection of doxorubicin hydrochloride in rats induced local leakage of the skin tissue were studied by detecting the swelling extinction index, ecchymosis incidence, scar detachment rate and pathological sections. Therapeutic effect of the model. Results: Compared with the control group, the traditional Chinese medicine “wounding plaster ” was applied to the local dermal tissue injury model induced by chemotherapeutic drugs, the dorsal skin lesions of rats were light red, mild edema, ulcer smaller, and the swelling subsided time was shorter , Low incidence of ecchymosis and high rate of scar loss, pathological tissue showed diffuse inflammatory cell infiltration, epidermis intact. Conclusion: Traditional Chinese medicine “trauma cream” has a good therapeutic effect on the local skin tissue damage caused by chemotherapy drugs.