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目的 :探讨Ⅱ型糖尿病患者早期肾脏损害中白蛋白与转铁蛋白的关系。采用放射免疫分析法 (RIA)检测Ⅱ型糖尿病患者 76例 ,正常对照组 5 2例的 2 4小时尿转铁蛋白 (TRF) ,白蛋白 (ALB)及 2 4小时尿蛋白的含量。结果Ⅱ型糖尿病ALB阳性率 30 % (2 2 / 76 ) ,TRF值阳性率 5 2 .6 % (40 / 76 )均高于正常对照组 ,有显著差异 (P <0 .0 1) ,糖尿病组ALB、TRF之间敏感性比较有显著性差异 (χ2 =4.41,P值 <0 .0 5 )。提示尿白蛋白、转铁蛋白可作为糖尿病肾病早期检测指标 ,而转铁蛋白更敏感。
Objective: To investigate the relationship between albumin and transferrin in early stage renal damage in type 2 diabetic patients. Radioimmunoassay (RIA) was used to detect 24 hours urinary transferrin (TRF), albumin (ALB) and 24 hours urinary protein in 76 patients with type 2 diabetes mellitus and 52 normal controls. Results The positive rate of type 2 diabetes was 30% (2 2/76) and the positive rate of TRF was 52.6% (40/76), which was significantly higher than that of normal control group (P <0.01) Group ALB, TRF sensitivity between the significant differences (χ2 = 4.41, P value <0. 05). Tip urinary albumin, transferrin can be used as early detection of diabetic nephropathy indicators, and transferrin more sensitive.