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小鼠灌胃给予辐射防护有效剂量17α-乙炔-雌三醇-3-环戊醚(CEE_3)后10天内,骨髓与脾脏CFU-S都出现一过性抑制,到15天时恢复正常。CEE_3对CFU-S的抑制程度和辐射防护效价与药量有一定关系。切除脾脏或切除肾上腺可减轻CEE_3对造血干细胞的抑制作用。照前切除脾脏可提高照射小鼠骨髓CFU-S含量,但不能提高CEE_3对造血干细胞的防护效果。切除肾上腺对照射小鼠骨髓CFU-S的含量无明显影响,但可明显减低CEE_3对照射小鼠CFU-S的防护效果。对CEE_3等雌激素的辐射防护作用机理进行简短的讨论。
Three days after intragastric administration of radioprotective effective dose of 17α-acetylene-estriol-3-cyclopentylether (CEE_3), mice had transient inhibition of CFU-S in both bone marrow and spleen and returned to normal by 15 days. The degree of inhibition of CFU-S by CEE_3 and the radiation protection titer have a certain relationship with the drug dose. Resection of the spleen or removal of the adrenal glands can reduce the inhibitory effect of CEE_3 on hematopoietic stem cells. Spleenectomy before irradiation can increase the CFU-S content in irradiated bone marrow, but it can not increase the protective effect of CEE_3 on hematopoietic stem cells. The removal of the adrenal gland had no significant effect on the CFU-S content in irradiated bone marrow, but it could significantly reduce the protective effect of CEE_3 on irradiated CFU-S. The mechanism of radiation protection of estrogens such as CEE_3 is briefly discussed.