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研究了创伤(闭合伤、截肢伤、烧伤)后小鼠不同来源淋巴细胞(脾脏、胸腺、肠系膜淋巴结)白介素2受体(IL-2R)mRNA及IL-2R的变化,并观察了创伤后血清,巨噬细胞、Ts细胞的抑制作用。结果显示:3种类型创伤组小鼠不同来源淋巴细胞IL-2RmRNA水平均降低,淋巴细胞膜IL-2R的变化与此相一致,二者呈非常显著的正相关。创伤后血清、巨噬细胞、Ts细胞在体外均可抑制正常小鼠脾细胞IL-2RmRNA及IL-2R水平,去除创伤小鼠脾细胞中的巨噬细胞或Ts细胞均可致IL-2RmRNA及IL-2R水平的提高。提示创伤后血清、巨噬细胞、Ts细胞可通过抑制淋巴细胞IL-2R的转录从而导致淋巴细胞膜IL-2R的减少。
To study the changes of interleukin 2 receptor (IL-2R) mRNA and IL-2R in different lymphocytes (spleen, thymus and mesenteric lymph nodes) in mice after trauma (closed injury, amputation, burn) , Macrophage, Ts cell inhibition. The results showed that the levels of IL-2R mRNA in lymphocytes of different types of trauma mice decreased, and the changes of IL-2R in lymphocyte membrane were consistent with the three types of wounds. The two showed a very significant positive correlation. Traumatic serum, macrophages, Ts cells in vitro can inhibit the normal mouse spleen IL-2R mRNA and IL-2R levels, removal of trauma mouse spleen cells in macrophages or Ts cells can cause IL-2R mRNA and IL-2R levels increased. It is suggested that posttraumatic serum, macrophages and Ts cells can induce the decrease of IL-2R in lymphocytes by inhibiting the transcription of IL-2R in lymphocytes.