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目的:观察普贝生(控释前列腺素E2栓剂)用于足月妊娠计划分娩的效果。方法:将在我院待产的孕妇312例随机分为两组。实验组172例,采用普贝生1枚放置于阴道后穹隆;对照组150例,用小剂量催产素静脉滴注引产。比较两组产妇用药后12h宫颈成熟效果、用药至临产所需时间、分娩方式、新生儿Apgar评分。结果:实验组产妇用药后12h宫颈评分,135例提高≥3,对照组47例用药12h后宫颈评分提高≥3,两组间比较差异有显著性意义(P<0.05)。实验组用药至临产所需时间为(7.78±4.05)h,对照组为(21.55土10.46)h,两组比较有显著性差异(P<0.05)。实验组的剖宫产率为14.00%,对照组剖宫产率为48.00%,其中有两组比较,差异有显著性意义(P<0.05)。两组新生儿出生后1min、5minApgar评分无显著性差异(P>0.05)。结论:普贝生可安全、有效地用于足月妊娠计划分娩。
OBJECTIVE: To observe the effect of Plesin (controlled release prostaglandin E2 suppository) for planned delivery of term pregnancy. Methods: 312 pregnant women to be produced in our hospital were randomly divided into two groups. In the experimental group, 172 cases were treated with Plesi and placed in the posterior vaginal vault. In the control group, 150 cases were given intravenous drip of oxytocin. The effect of cervical ripening at 12h after maternal drug administration, the time required for delivery to labor, delivery mode and Apgar score of neonates were compared between the two groups. Results: In the experimental group, the cervical score at 12h was increased by 135% in the experimental group, while that in the control group increased by ≥3 after 12h. The difference between the two groups was significant (P <0.05). The experimental group took (7.78 ± 4.05) h and the control group was (21.55 ± 10.46) h, the difference between the two groups was significant (P <0.05). The cesarean section rate was 14.00% in the experimental group and 48.00% in the control group. There was significant difference between the two groups (P <0.05). Two groups of newborns 1min after birth, 5minApgar no significant difference (P> 0.05). CONCLUSIONS: Przewalski may safely and effectively use scheduled pregnancy delivery.