论文部分内容阅读
目的:探讨终末期尿毒症患者血液透析对外周血T细胞亚群功能的影响。方法:选择从2013年6月-2014年7月于温岭市第一人民医院接受治疗的100例终末期尿毒症患者,按照随机数字表法分为A组和B组,另外选取30例正常体检者作为对照C组。采用流式细胞仪法对所有研究资料的外周血的CD3、CD4、CD8、CD4/CD8进行检测,并对数据进行比较分析。结果:尿毒症患者外周血的CD3、CD4、CD4/CD8明显低于正常对照组,CD8高于对照组,差异具有统计学意义(P<0.05);血液透析后患者的CD3、CD4、CD8、CD4/CD8明显优于透析前,而透析尿毒症组患者外周血的CD3、CD4、CD4/CD8明显高于未透析尿毒症组,CD8低于未透析尿毒症组,差异均具有统计学意义(P<0.05)。结论:血液透析法可以显著提高终末期尿毒症患者T细胞亚群的免疫功能,安全可靠,适合临床长期推广应用。
Objective: To investigate the effect of hemodialysis on the function of T lymphocyte subsets in peripheral blood in patients with end-stage uremia. Methods: A total of 100 patients with end-stage uremia treated in Wenling First People’s Hospital from June 2013 to July 2014 were randomly divided into group A and group B according to the random number table method. In addition, 30 cases of normal physical examination As control C group. Flow cytometry was used to detect CD3, CD4, CD8, CD4 / CD8 in peripheral blood of all the research data, and the data were analyzed comparatively. Results: The levels of CD3, CD4 and CD4 / CD8 in the peripheral blood of patients with uremia were significantly lower than those in the normal control group and CD8 was higher than those in the control group (P <0.05). The levels of CD3, CD4, CD8, CD4 / CD8 was significantly better than that before dialysis, but the levels of CD3, CD4 and CD4 / CD8 in peripheral blood of patients in dialysis uremia group were significantly higher than those in non-dialysis uremia group and CD8 was lower than those in non-dialysis uremia group P <0.05). Conclusion: Hemodialysis can significantly improve the immune function of T-cell subsets in patients with end-stage uremia, which is safe and reliable and is suitable for long-term clinical application.