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本实验以大鼠脊髓损伤(SCI,50gcm)模型,研究TRH对SCI脂质过氧化的影响。结果表明,于SCI后立即iv不同剂量的TRH(0.2mg/kg,0.6mg/kg,2.0mg/kg,每小时1次,连续4次),可显著地抑制伤段脊髓组织脂质过氧化反应,使丙二醛(MDA)含量显著降低,并呈剂量依赖关系j;TRH还可使组织超氧化物歧化酶(SOD)活性明显升高。提示TRH抗SCI脂质过氧化反应是通过升高SOD活性,清除自由基(尤其是氧自由基)介导的,它可能是1种有效的自由基清除剂。
In this study, rat spinal cord injury (SCI, 50gcm) model to study the impact of TRH on SCI lipid peroxidation. The results showed that different doses of TRH (0.2 mg / kg, 0.6 mg / kg, 2.0 mg / kg, once per hour for 4 consecutive times) immediately after SCI significantly inhibited lipid peroxidation in injured spinal cord tissue Reaction, the content of malondialdehyde (MDA) significantly decreased, and in a dose-dependent manner; TRH also significantly increased the activity of tissue superoxide dismutase (SOD). Tip TRH anti-SCI lipid peroxidation is through the increase of SOD activity, scavenging free radicals (especially oxygen free radicals) mediated, it may be a valid free radical scavenger.