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目的比较硝苯地平和拉贝洛尔治疗重度妊娠期高血压疾病的临床效果及安全性。方法将重度妊娠期高血压疾病患者221例随机分为观察组110例和对照组111例,在给予常规硫酸镁静脉滴注治疗的基础上,观察组给予硝苯地平控释片口服治疗,对照组给予拉贝洛尔静脉滴注治疗,比较2组治疗前后血压、血液黏度、血细胞压积、24h尿蛋白量变化情况,并比较2组患者妊娠结局和分娩方式。结果治疗后2组患者血压水平、血液黏度、血细胞压积、24h尿蛋白量均显著低于治疗前,差异均有统计学意义(P<0.05);2组总有效率、妊娠结局比较差异均无统计学意义(P>0.05)。结论硝苯地平联合硫酸镁治疗对于重度妊娠期高血压疾病患者是一种可行、有效且经济适用的治疗方案,值得进一步研究推广。
Objective To compare the clinical efficacy and safety of nifedipine and labetalol in the treatment of severe gestational hypertension. Methods One hundred and twenty-one patients with severe gestational hypertension were randomly divided into observation group (n = 110) and control group (n = 111). On the basis of conventional magnesium sulfate intravenous drip treatment, the observation group was given nifedipine controlled release tablets orally, The rabbits were given intravenous infusion of labetalol. The changes of blood pressure, blood viscosity, hematocrit and urine protein in 24 hours before and after treatment were compared. The pregnancy outcome and delivery mode were compared between the two groups. Results After treatment, blood pressure, blood viscosity, hematocrit and urine protein in 24 hours were significantly lower than those before treatment in both groups (P <0.05). The total effective rate and pregnancy outcome in the two groups were significantly lower than those before treatment No statistical significance (P> 0.05). Conclusion Nifedipine combined with magnesium sulfate is a feasible, effective and economical treatment for patients with severe pregnancy-induced hypertension, which is worth further study and promotion.