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目的观察凋亡抑制蛋白Survivin在胃癌组织中的表达,探讨其表达与C-erbB-2、Ki- 67增殖指数的相关性及其临床意义。方法应用免疫组织化学法检测92例胃癌组织中Survivin、C-erbB-2、Ki-67的表达,分析Survivin表达与临床病理因素、预后、C-erbB-2表达及Ki-67增殖指数的关系。结果Survivin在胃癌组织中的表达率为37%,正常胃组织中未见表达。Survivin表达与胃癌细胞分化、浸润深度、淋巴结转移、TNM分期明显相关(P＜0．05),Survivin阳性表达的5年生存率(26．5%)明显低于阴性表达者(51．7%,P＜0．05)。C-erhB-2表达率为47-8%,C-erbB-2在Sur- vivin阳性表达组的表达率(76．5%)明显高于在Survivin阴性表达组(31．0%,P＜0．05),Survivin阳性表达的胃癌组织Ki-67增殖指数(43．74±19．32)%明显高于Survivin阴性表达的胃癌组织增殖指数(21．87±19．40)%(P＜0．05)。结论Survivin表达可作为判断胃癌恶性程度和预后的重要指标,与C-erbB-2表达正相关,可促进胃癌细胞增殖。
Objective To investigate the expression of survivin protein in gastric carcinoma and its correlation with the proliferation index of C-erbB-2 and Ki- 67 and its clinical significance. Methods The expressions of Survivin, C-erbB-2 and Ki-67 in 92 gastric cancer tissues were detected by immunohistochemistry. The relationship between Survivin expression and clinical pathological factors, prognosis, C-erbB-2 and Ki-67 proliferation index . Results The expression rate of Survivin in gastric cancer was 37%, which was not found in normal gastric tissues. Survivin expression was significantly associated with gastric cancer cell differentiation, depth of invasion, lymph node metastasis and TNM staging (P <0.05), and the 5-year survival rate (26.5%) of Survivin positive expression was significantly lower than that of negative expression (51.7% , P <0.05). The positive rate of C-erbB-2 was 47-8%, and the positive rate of C-erbB-2 in Survivin-positive group was significantly higher than that in Survivin-negative group (31.0%, P < 0.05). Ki-67 proliferation index (43.74 ± 19.32)% in Survivin positive gastric cancer tissues was significantly higher than that in Survivin negative gastric cancer tissues (21.87 ± 19.40)% (P < 0.05). Conclusion The expression of Survivin can be used as an important index to judge the malignant degree and prognosis of gastric cancer. It is positively correlated with the expression of C-erbB-2 and can promote the proliferation of gastric cancer cells.