论文部分内容阅读
采用Ｌａｎｇｅｎｄｏｒｆｆ灌流装置灌流离体大鼠心脏，并施加强度为１０伏、频率为６００次／分的电驱动，心脏表现出收缩舒张功能下降，乳酸脱氢酶（ＬＤＨ）漏出，谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性降低，丙二醛（ＭＤＡ）的生成增多及组织和线粒体Ｃａ２＋超载等变化。不同浓度Ｍｇ２＋溶液灌注疲劳大鼠心脏后表明，适宜浓度的Ｍｇ２＋对上述变化有良好的改善作用。
The isolated rat hearts were perfused with a Langendorff perfusion device and subjected to an electric drive at a frequency of 600 beats / min at an intensity of 10 volts. The heart showed a decrease in systolic and diastolic function, leakage of lactate dehydrogenase (LDH), glutathione Oxidase (GSH-Px) activity decreased, the formation of malondialdehyde (MDA) increased and tissue and mitochondrial Ca2 + overload and other changes. Different concentrations of Mg2 + solution perfusion fatigue rat heart shows that the appropriate concentration of Mg2 + on the above changes have a good effect.