论文部分内容阅读
采用Langendorff灌流装置灌流离体大鼠心脏,并施加强度为10伏、频率为600次/分的电驱动,心脏表现出收缩舒张功能下降,乳酸脱氢酶(LDH)漏出,谷胱甘肽过氧化物酶(GSH-Px)活性降低,丙二醛(MDA)的生成增多及组织和线粒体Ca2+超载等变化。不同浓度Mg2+溶液灌注疲劳大鼠心脏后表明,适宜浓度的Mg2+对上述变化有良好的改善作用。
The isolated rat hearts were perfused with a Langendorff perfusion device and subjected to an electric drive at a frequency of 600 beats / min at an intensity of 10 volts. The heart showed a decrease in systolic and diastolic function, leakage of lactate dehydrogenase (LDH), glutathione Oxidase (GSH-Px) activity decreased, the formation of malondialdehyde (MDA) increased and tissue and mitochondrial Ca2 + overload and other changes. Different concentrations of Mg2 + solution perfusion fatigue rat heart shows that the appropriate concentration of Mg2 + on the above changes have a good effect.