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目的:探讨血清唾液酸(SA)和超敏C反应蛋白(hs-CRP)与高血压前期的关系及临床意义。方法:将160例2012年10月至2014年9月于我院进行体检者分为正常血压组、高血压前期组和高血压组,分别测量所有研究对象的血压、身高和体重,检测所有对象同一天的血清SA、hs-CRP、血清总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、三酰甘油(TG)和空腹血糖(FPG)水平,采用多元线性回归方法探究血清SA和hs-CRP水平对收缩压(SBP)和舒张压(DBP)的影响。结果:三组间的DBP、SBP、BMI、SA、hs-CRP、TC、LDL、HDL和FBG水平差异均具有统计学意义(P<0.05),其中BMI、SA和hs-CRP水平随着血压升高逐渐上升,而HDL水平逐渐下降(P<0.05);TC和LDL水平仅高血压组高于正常血压组,高血压前期组与正常血压组的TC和LDL水平差异无统计学意义(P<0.05);多元线性回归发现:BMI、SA、hs-CRP和FBG均与SBP成正相关,BMI、SA、hs-CRP和LDL均与DBP呈正相关。结论:血清SA与hs-CRP水平均与血压值呈现独立正相关,可作为高血压前期的评估指标。
Objective: To investigate the relationship between serum sialic acid (SA) and high-sensitivity C-reactive protein (hs-CRP) and prehypertension and its clinical significance. Methods: 160 cases from October 2012 to September 2014 in our hospital were divided into normotensive group, prehypertensive group and hypertension group, all subjects were measured blood pressure, height and weight, all subjects were tested Serum SA, hs-CRP, TC, LDL, HDL, triglyceride (TG) and fasting plasma glucose (FPG) were measured on the same day. Regression method to explore the impact of serum SA and hs-CRP on systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results: The differences of DBP, SBP, BMI, SA, hs-CRP, TC, LDL, HDL and FBG among the three groups were statistically significant (P <0.05). The levels of BMI, SA and hs- (P <0.05). The levels of TC and LDL in TC and LDL were only higher in hypertension group than in normal blood pressure group, there was no significant difference in TC and LDL levels between pre-hypertension group and normal blood pressure group (P <0.05). Multiple linear regression showed that BMI, SA, hs-CRP and FBG were positively correlated with SBP, while BMI, SA, hs-CRP and LDL were positively correlated with DBP. Conclusion: The levels of serum SA and hs-CRP both have an independent and positive correlation with the blood pressure, which can be used as the evaluation index of prehypertension.