本文报道上海长征医院儿科,首先用国产丙酸培氯松气雾剂(BDA)治疗重症顽固小儿哮喘60例,随访6年,有效率达91.7%。喷用方法须正确、合理,一般每日喷用剂量为150～300μg,症状控制后,量可酌减.35例依赖皮质素患儿,能全部由BDA替代.长期应用既无生长受抑又无肾上腺皮质功能受限。8.3%病例口咽部有短暂霉菌生长,酮康唑气雾剂可阻止其发生。哮喘并发异位性皮炎和/或过敏性鼻炎,BDA与酮替芬合用,疗效较理想。 This article reports the Shanghai Changzheng Hospital Pediatrics, first of all with domestic intramuscular budesonide aerosol (BDA) treatment of 60 cases of severe refractory pediatric asthma, 6 years follow-up, the effective rate of 91.7%. Spraying method must be correct and reasonable, the general daily dose of 150 ~ 300μg spray, the symptoms can be reduced by the amount of discretion .35 cases of cortical children can be replaced by BDA. Long-term application neither growth inhibition and No adrenocortical function is limited. Shorter mold growth was observed in oropharynx in 8.3% of cases, and ketoconazole aerosol prevented it from occurring. Asthma complicated by atopic dermatitis and / or allergic rhinitis, BDA and ketotifen combined, the more effective.