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目的探讨脑苷聚肽(凯洛欣)在脑梗死急性期治疗中的神经保护作用。方法将2005年3月至2007年12月辽宁省抚顺矿业集团总医院神经内三科208例脑梗死急性期患者分为2组。治疗组(108例)发病24h内用凯洛欣注射液16mL/d静脉滴注,2周为1个疗程,然后4mL肌注,每日2次,维持4周。对照组(100例)发病24h内开始用胞二磷胆碱注射液1.0g/d静脉滴注,共6周。评价两组疗效。结果治疗组与对照组显效率分别为63.9%,30%,有效率92.6%,70%,两组显效率及有效率比较,差异有统计学意义(P<0.01)。结论凯洛欣具有较好的神经保护作用,早期应用可促进神经功能恢复、改善预后。
Objective To investigate the neuroprotective effect of cerebroside (Kellocera) in the treatment of acute cerebral infarction. Methods From March 2005 to December 2007, 208 patients with acute cerebral infarction were divided into two groups in the department of neurology, Fushun Mining Group General Hospital, Liaoning Province. The treatment group (108 cases) within 24 hours of onset with Kelocaoxin injection 16mL / d intravenous infusion, 2 weeks for a course of treatment, and then 4mL intramuscular injection, 2 times daily for 4 weeks. The control group (100 cases) started within 24 hours of intravenous citicoline injection 1.0g / d intravenous infusion, a total of 6 weeks. Evaluation of two groups of curative effect. Results The effective rates of the treatment group and the control group were 63.9%, 30%, 92.6%, 70% respectively. There was significant difference between the two groups (P <0.01). Conclusion Keluoxin has a good neuroprotective effect, early application can promote neurological recovery, improve prognosis.