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目的探讨并验证使用间接法建立杭州地区妊娠中期孕妇血清微量元素参考区间的可行性和可靠性。方法回顾性分析浙江省人民医院检验中心2015年1月-2016年12月3 406例妊娠中期孕妇铜、铁、锌检测结果,同时收集151例育龄期健康妇女作为对照组,使用非参数排序法获得参考区间。另选择20例健康妊娠中期孕妇验证参考区间。结果妊娠中期孕妇组Cu为(30.44±5.27)μmol/L;Fe为(15.79±6.63)μmol/L;Zn为(9.88±1.67)μmol/L,与对照组比较,Cu、Fe、Zn差异均有统计学意义(P<0.05)。使用杜奇法联合非参数排序法计算获得的孕妇微量元素参考区间,Cu:22.16μmol/L~39.53μmol/L、Fe:5.9μmol/L~24.3μmol/L、Zn:7.26μmol/L~12.18μmol/L。间接法建立的参考区间用20例健康孕妇参考个体验证通过。结论通过间接法建立妊娠中期孕妇血清微量元素参考区间,方法简单、可靠,为临床医生对本地区孕妇提供营养保健指导有重要意义。
Objective To explore and verify the feasibility and reliability of using indirect method to establish the reference serum trace elements of pregnant women in the second trimester of pregnancy in Hangzhou area. Methods A retrospective analysis of Zhejiang Province People’s Hospital Test Center from January 2015 to December 2016 3 406 cases of pregnant women during the third trimester of pregnancy copper, iron, zinc test results, while 151 healthy women of childbearing age were collected as a control group, non-parametric ranking method Get the reference interval. Another 20 cases of healthy pregnancy in the second trimester to verify the reference interval. Results Compared with the control group, the differences of Cu, Fe and Zn in the pregnant women were (30.44 ± 5.27) μmol / L and (15.79 ± 6.63) μmol / L respectively, and Zn was 9.88 ± 1.67 μmol / L There was statistical significance (P <0.05). The reference intervals of trace elements in pregnant women calculated by Duchess method and nonparametric sorting method were Cu: 22.16μmol / L ~ 39.53μmol / L, Fe: 5.9μmol / L ~ 24.3μmol / L, Zn: 7.26μmol / L ~ 12.18 μmol / L. The reference interval established by indirect method was verified by reference to 20 healthy pregnant women. Conclusion Indirect method to establish the reference interval of trace elements in pregnant women during the second trimester of pregnancy is simple and reliable, which is of great significance for clinicians to provide nutrition and health guidance to pregnant women in the region.