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设双氢青蒿素3天疗程240mg、5天疗程360mg和7天疗程480mg三组,各治疗恶性疟30例,进行疗效比较。结果表明,三组所治疗的病人平均退热时间和原虫转的时间相似,原虫复燃率则7天疗程组(无复燃)和5天疗程组(5.6%)显著低于3天疗程组(52.0%)。三组均未发现临床不良反应。7例患者进行杀虫速度观察,表明双氢青蒿素清除95%原虫时间为16h,推荐7天疗程480mg为临床适宜治疗量。
Set dihydroartemisinin three days course 240mg, five days course 360mg and seven days course 480mg three groups, the treatment of 30 cases of falciparum malaria, the curative effect comparison. The results showed that the average duration of fever in the three treatment groups was similar to that of the protozoal, and the rates of protozoal relapse were significantly lower in the 7-day treatment group (no resurgence) and the 5-day treatment group (5.6%) than in the 3 days Treatment group (52.0%). Three groups were found no clinical adverse reactions. Seven patients were observed for insecticidal speed, indicating that dihydroartemisinin clearance of 95% protozoa for 16h, recommended 7 days course of 480mg for the appropriate clinical treatment.