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G protein coupled receptors(GPCRs)are transmembrane receptor proteins,which allow signals to transfer across membrane.GPCRs include a large number of receptors,different receptors mediated different signaling pathways of GPCRs-adenylyl cyclase(AC)-cyclic adenosine 3’,5’-monophosphate(c AMP),including β2 adrenergic receptors(β2-ARs)-AC-c AMP signaling pathways,E-prostanoid2/4(EP2/4)-AC-cA MP signaling pathways.Regulatory proteins,such as G protein coupled receptor kinases(GRKs)andβ-arrestins,play important modulatory roles in GPCRs signaling pathway.GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response.Rheumatoid arthritis(RA)is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response.This article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.
G protein coupled receptors (GPCRs) are transmembrane receptor proteins, which allow signals to transfer across membranes. GPCRs include a large number of receptors, different receptors mediated different signaling pathways of GPCRs-adenylyl cyclase (AC) -cyclic adenosine 3 ’, 5’ -monophosphate (c AMP), including β2 adrenergic receptors (β2-ARs) -AC-c AMP signaling pathways, E-prostanoid2 / 4 (EP2 / 4) -AC-cA MP signaling pathways. receptor kinases (GRKs) and β-arrestins, play important modulatory roles in GPCRs signaling pathway. GPCRs signaling pathway and regulatory proteins implicate the pathogenesis process of inflammatory and immune response. Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis and accompanied with inflammatory and abnormal immune response. this article review the advances on GPCRs signaling pathway implicating in the inflammatory and immune response of RA.