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目的:观察氟脲嘧啶脱氧核苷(FUDR)治疗食管癌的疗效,探索化疗的最佳方案,提高其远期疗效,延长患者的生存期,并提高其生存质量。方法:168例食管癌患者分为试验组(n=60),手术后给予以FUDR为主的化疗;对照组(n=60),手术后给予以5-氟脲嘧啶(5-FU)为主的化疗;单纯手术组(n=48),术后未经过化疗。结果:全部病例均随访5年,5年生存率对照组高于单纯手术组,差异有显著性(P<0.05),而试验组高于单纯手术组,两组比较,差异有非常显著性(P<0.01)。化疗副作用、生存质量试验组优于对照组,差异有非常显著性(P<0.01)。结论:以FUDR为主联合化疗治疗食管癌效果良好,而副作用较以5-FU为主的化疗明显减低,生存质量明显提高。
OBJECTIVE: To observe the curative effect of FUDR on esophageal cancer, explore the best plan of chemotherapy, improve its long-term curative effect, prolong the survival period of patients and improve its quality of life. METHODS: A total of 168 patients with esophageal cancer were divided into experimental group (n = 60) and FUDR-based chemotherapy after operation. The control group (n = 60) received 5-fluorouracil The main chemotherapy; simple surgery group (n = 48), after surgery without chemotherapy. Results: All patients were followed up for 5 years. The 5-year survival rate in the control group was higher than that in the simple operation group (P <0.05), while the experimental group was higher than the simple operation group. There was significant difference between the two groups P <0.01). Chemotherapy side effects, quality of life test group than the control group, the difference was significant (P <0.01). Conclusion: FUDR-based combination chemotherapy is effective in treating esophageal cancer, while the side effects are significantly lower than that of 5-FU-based chemotherapy, and the quality of life is significantly improved.