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目的 :探讨广西汉族 2型糖尿病 (DM)合并高血压与 ACE基因 I/ D多态性的相关情况及其与血脂代谢的关系。方法 :采用多聚酶链反应 (PCR)技术 ,对 81例广西地区汉族 2型 DM无合并高血压患者和 39例 2型 DM合并高血压患者及 10 0名汉族正常对照的 ACE基因插入 /缺失 (I/ D)多态性及血脂进行检测。结果 :2型 DM合并高血压组 ACE基因各等位基因及基因型频率与正常对照组及无合并高血压组比较均无统计学意义 (P >0 .0 5 )。 2型 DM合并高血压 DD基因型组及 ID基因型组甘油三酯 (TG)、总胆固醇 (TC)及低密度脂蛋白胆固醇 (L DL- C)高于正常组 ,高密度脂蛋白胆固醇 (HDL- C)低于正常组 (P<0 .0 5 ) ;II基因型组 TG、TC及 L DL- C低于 DD基因型组及 ID基因型组 (P <0 .0 5 ) ,与正常组对照组比较无统计学意义 ,HDL - C高于 DD基因型组及 ID基因型 (P <0 .0 5 ) ;ID基因型组 TG高于正常组、DD基因型组及 II基因型组 (P <0 .0 5 )。结论 :广西地区汉族 2型 DM合并高血压与 ACE基因 I/ D多态性无关联。 2型 DM合并高血压 DD基因型及 ID基因型者与正常人比较更易患高甘油三酯血症、高总胆固醇血症及高低密度脂蛋白胆固醇血症 ,II基因型者不易患高脂血症 ;ID基因型者更易患更高甘油三酯血症
Objective: To investigate the relationship between type 2 diabetes mellitus (DM) with hypertension and ACE gene I / D polymorphism in Guangxi Han and its relationship with lipid metabolism. Methods: Polymerase chain reaction (PCR) was used to examine the ACE gene insertion / deletion in 81 Han Chinese patients with type 2 DM without hypertension and 39 type 2 DM patients with hypertension in China and 10 normal Han controls / D) Polymorphism and blood lipids were detected. Results: The genotype and allele frequencies of ACE gene in type 2 diabetes mellitus combined with hypertension group were not significantly different from those in control group and without hypertension group (P> 0.05). The levels of triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (L DL-C) in type 2 diabetes mellitus with DD genotype and ID genotype were significantly higher than those in normal group, high-density lipoprotein cholesterol HDL-C) were lower than those in normal group (P <0.05); TG, TC and L DL-C in genotype II were lower than those in genotype DD and ID (P <0.05) HDL - C was higher than DD genotype and ID genotype in normal control group (P <0.05); ID genotype group TG was higher than normal group, DD genotype group and II genotype Group (P <0.05). Conclusion: There is no association between type 2 DM hypertension and ACE gene I / D polymorphism in Guangxi Han population. Type 2 DM with hypertension DD genotype and ID genotype were more susceptible to hypertriglyceridemia, hypercholesterolemia and high and low density lipoprotein cholesterol compared with normal people, genotype II are not susceptible to high fat Serum; ID genotypes are more likely to have hypertriglyceridemia