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目的：观察施维舒对无水乙醇诱发大鼠急性胃粘膜损伤的防治作用。方法：将５６只ＳＤ大鼠分为正常对照（Ⅰ）、预防（Ⅱ）、治疗（Ⅲ）３个大组，再分预防对照（Ⅱａ）、施维舒预防（Ⅱｂ）、雷尼替丁预防（Ⅱｃ）、治疗对照（Ⅲａ）、施维舒治疗（Ⅲｂ）、雷尼替丁治疗（Ⅲｃ）等亚组。分别测定胃粘膜血流量（ＧＭＢＦ）、胃粘膜跨膜电位（ＰＤ）、损伤指数（ＵＩ）等多项指标。结果：Ⅱｂ、Ⅲｂ组与各自对照组比较发现，ＵＩ均显著降低（Ｐ＜０．０ｌ）；ＧＭＢＦ增加（Ｐ＜０．０１），其中Ⅲｂ组尚高于Ⅰ组（Ｐ＜０．０５）；ＰＤ升高（Ｐ＜０．０１）；胃粘膜氨基己糖、磷脂含量增加（Ｐ＜０．０１）；疏水性增强（Ｐ＜０．０１）。结论：施维舒是一种良好的胃粘膜细胞保护剂。
Objective: To observe the prevention and treatment of Schweitzer on acute gastric mucosal injury induced by ethanol in rats. Methods: Fifty - six SD rats were divided into three groups: normal control group (Ⅰ), prevention group (Ⅱ) and treatment group (Ⅲ). The control group (Ⅱa), prevention of schizophyllan (Ⅱb) and prevention of ranitidine Ⅱc), treatment control (Ⅲa), Shiweishu treatment (Ⅲb), ranitidine treatment (Ⅲc) and other subgroups. Gastric mucosal blood flow (GMBF), gastric mucosal transmembrane potential (PD), injury index (UI) and other indicators were measured. Results: Compared with the control group, the levels of UI were significantly lower in group Ⅱb and Ⅲb (P <0.01); the GMBF was increased (P <0.01), and that in group Ⅲb was still higher than that in group Ⅰ (P <0.05) ; PD increased (P <0.01); gastric mucosal hexosamine, phospholipid content increased (P <0.01); hydrophobicity increased (P <0.01). Conclusion: Schweitzer is a good gastric mucosal cell protectant.