碱性成纤维细胞生长因子是体内最重要的生长因子之一,可由骨髓基质细胞和成骨细胞等分泌,储存于细胞外基质中,通过受体介导以自分泌/旁分泌方式起作用。实验证明碱性成纤维细胞生长因子能促进去卵巢大鼠骨形成,增加骨量,改善骨的微结构。此外,它还能促进骨质疏松性骨折的愈合。碱性成纤维细胞生长因子富有巨大的潜力,有望开辟骨质疏松症治疗的新方法。 Basic fibroblast growth factor is one of the most important growth factors in the body. It can be secreted by bone marrow stromal cells and osteoblasts, stored in the extracellular matrix, and acted in an autocrine / paracrine manner through receptor-mediated. Experiments show that basic fibroblast growth factor can promote bone formation in ovariectomized rats, increase bone mass, and improve the microstructure of bone. In addition, it promotes the healing of osteoporotic fractures. Basic fibroblast growth factor has great potential, is expected to open up new ways to treat osteoporosis.