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目的:探讨新疆地区维、汉2个民族血清胆红素水平与早发冠心病的关系。方法:将766例冠状动脉造影患者(男性≤55岁,女性≤65岁)分为早发冠心病组372例,其中维族112例,汉族260例;正常对照组394例,其中维族136例,汉族258例。冠状动脉病变从是否患有冠心病、病变支数及冠状动脉Gensini总积分3个方面分析。结果:汉族早发冠心病组总胆红素、间接胆红素低于对照组,维族早发冠心病组总胆红素、直接胆红素低于对照组,差异均有统计学意义(P<0.05)。早发冠心病组维族总胆红素及直接胆红素低于汉族,差异有统计学意义(P<0.05)。维族多支病变总胆红素水平低于单支病变,双支、多支病变直接胆红素水平低于单支病变,汉族双支、多支病变总胆红素、直接胆红素、间接胆红素水平低于单支病变,差异均有统计学意义(P<0.05)。多元逐步回归分析显示,引入其他危险因素后,汉族间接胆红素、维族直接胆红素均与冠状动脉病变程度呈负相关(P<0.05)。结论:血清胆红素可能是早发冠心病的独立危险因素。维族直接胆红素、汉族间接胆红素对预测冠状动脉粥样硬化严重程度有一定意义。
Objective: To investigate the relationship between serum bilirubin level and premature coronary heart disease in Victoria and Han ethnic groups in Xinjiang. Methods: A total of 766 coronary angiography patients (≤55 years old and ≤65 years old) were divided into premature coronary heart disease group (372 cases), including 112 Uygurs and 260 Han nationality patients, 394 normal controls (136 Uygur patients, 258 Han cases. Coronary artery disease from the presence of coronary heart disease, lesion count and coronary Gensini total score of 3 aspects. Results: The serum levels of total bilirubin and indirect bilirubin in Han nationality with premature coronary heart disease were lower than those in control group. The total bilirubin and direct bilirubin in Uighur premature coronary heart disease group were lower than those in control group (P <0.05). There was a significant difference between Uygur total bilirubin and direct bilirubin in Han nationality in premature coronary heart disease group (P <0.05). Uygur multi-branch disease total bilirubin levels lower than single-vessel disease, double-branch, multi-vessel disease direct bilirubin levels lower than single-vessel disease, Han double branch, multiple branch disease total bilirubin, direct bilirubin, indirect The level of bilirubin was lower than that of single vessel disease (P <0.05). Multivariate stepwise regression analysis showed that the indirect indirect bilirubin and Uygur direct bilirubin were negatively correlated with the degree of coronary artery disease (P <0.05) after other risk factors were introduced. Conclusion: Serum bilirubin may be an independent risk factor for premature coronary heart disease. Uygur direct bilirubin, Han indirect bilirubin to predict the severity of coronary atherosclerosis has some significance.