皮肤利什曼病的治疗通常采用20天锑剂注射疗法,但毒副作用较大。此外还有采用巴龙霉素(15％)配伍氯化甲基苄甲乙氧铵(MBCL,12％)或尿素(10％)用于治疗病人,效果亦不甚理想。 本文作者将巴龙霉素(15％)与庆大霉素(0.5％)配伍制成白软石蜡软膏WR279,396,用于治疗皮肤利什曼病,并与其它配方的疗效进行了比较。实验采用20克重的雄性BALB/c小鼠作为动物模型,剪去尾根部毛以暴露皮肤,皮下接种5×10~6个相应种的利 Skin leishmaniasis treatment usually use 20 days antimony injection therapy, but the toxic side effects. In addition, the use of paromomycin (15%) with methyl benzyl ammonium ethoxymethyl chloride (MBCL, 12%) or urea (10%) for the treatment of patients, the effect is not satisfactory. The authors combined paromomycin (15%) with gentamicin (0.5%) as a white soft paraffin ointment WR279,396 for the treatment of cutaneous leishmaniasis and compared its efficacy with other formulations. Twenty grams of male BALB / c mice were used as animal models. The tail hairs were cut off to expose the skin and subcutaneously inoculated with 5 × 10 ~ 6 corresponding species