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Spitzer 等最近指出,吸入β激动剂可导致哮喘患者病情恶化和死亡率增高,以往也有多篇相似的报告.但新西兰研究认为,哮喘患者的死亡与过分依赖吸入β激动剂有关,而并非药物的直接毒性作用。Spitzer 等的研究表明.舒喘灵与长效β激动剂酚丙喘宁并用,可使哮喘患者死亡的危险性或近期死亡增加,但因对照组的哮喘程度轻于观察组,此结果有一定局限性。当前对危重型哮喘患者迫切需要设病情相似的对照组,否则难以确定是β激动剂的直接作用还是由于对其过分依赖而未及时应用抗炎药物的结果。
Spitzer et al recently pointed out that inhaled beta agonist can lead to asthma exacerbations and increased mortality in the past there are many similar reports.But in New Zealand study, the death of asthma and excessive dependence on inhaled β agonists rather than drugs Direct toxicity. Spitzer and other studies have shown that salbutamol and long-acting β-agonist phenprostan combined with asthma can make the risk of death or recent death increased, but the control group had less asthma than the observation group, the result is certain limitation. There is an urgent need for a critically ill control group for critically ill patients with asthma, otherwise it is difficult to determine whether the direct effect of beta agonist is due to over-reliance on anti-inflammatory drugs.