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目的观察济宁地区普通人群20μg重组乙型肝炎疫苗(CHO细胞)免疫接种后抗-HBs转阳率,探讨疫苗免疫接种者抗-HBs转阳率的影响因素。方法 673名健康志愿者,分别于0、1、6月各接种20μg重组乙型肝炎疫苗。全程免疫后1～2个月采血,分离血清,采用ELISA法检测抗-HBs抗体,评价免疫效果,并分析年龄和性别对血清抗-HBs抗体转阳的影响。结果 673名健康志愿者接种20μg重组乙型肝炎疫苗(CHO细胞)后血清抗-HBs抗体阳性率为92.57%,不同年龄组抗体阳性率差异有统计学意义(P<0.001),男女抗-HBs抗体阳性率差异有统计学意义(P<0.001)。结论 20μg重组乙型肝炎疫苗(CHO细胞)免疫接种后血清抗-Hbs抗体阳性率较高。年龄、性别均可影响免疫接种后抗-HBs抗体转阳率。
Objective To observe the positive rate of anti-HBs after immunization with 20μg recombinant hepatitis B vaccine (CHO cell) in the general population in Jining, and to explore the influencing factors of anti-HBs positive rate in vaccinated patients. Methods Six hundred and seventy healthy volunteers were vaccinated with 20 μg of recombinant hepatitis B vaccine in January, June and June respectively. Blood samples were collected 1 to 2 months after the whole immunization, serum was separated, anti-HBs antibodies were detected by ELISA, immune effects were evaluated, and age and gender were analyzed for the influence of serum anti-HBs antibody on the setting of Yang. Results The positive rate of anti-HBs antibodies in 673 healthy volunteers after vaccination with 20 μg of recombinant hepatitis B vaccine (CHO cells) was 92.57%, the positive rate of antibody in different age groups was statistically significant (P <0.001), anti-HBs The difference of antibody positive rate was statistically significant (P <0.001). Conclusion The positive rate of serum anti-Hbs antibody after 20μg recombinant hepatitis B vaccine (CHO cell) immunization is high. Age and sex can affect the anti-HBs antibody positive rate after immunization.