论文部分内容阅读
本文报告一例应用灰黄霉素引起胆汁郁积性黄疸的病人。患者63岁,男性,于1973年5月因趾甲癣而用灰黄霉素治疗,每日500毫克。于9月病人主诉瘙痒和双侧眼睑浮肿,因考虑可能系该药的过敏反应而停用。当时肝功能检查正常。同年11月曾因高血压作过双侧肾动脉手术,并输过全血。在手术时发现胆结石,并作了胆囊切除,出院时肝功能正常。在同年12月因趾甲癣复发,再用灰黄霉素治疗,500毫克每日二次。3周后出现厌食、全身不适和瘙痒,但无发热、寒战、皮疹、腹痛或关节痛。病人无饮酒或应用其他药物史。出现症状10日后入院体检,发现巩膜黄染,但无慢性肝病的症状,肝、脾无肿大,右上腹深触诊亦无压痛。实验室检查:白细胞分类计数正常;
This article reports a case of griseofulvin caused by cholestatic jaundice patients. The patient, 63 years old, male, was treated with griseofulvin for the treatment of toenail ringworm in May 1973 at 500 mg daily. Patients complained of pruritus and bilateral eyelid edema in September because they considered possible allergic reactions to the drug. Liver function tests were normal. In the same year in November had bilateral hypertension due to renal artery surgery, and lost whole blood. Gallstones were found during surgery, and cholecystectomy was performed. Liver function was normal at discharge. In December the same year due to recurrence of toenail ringworm, and then griseofulvin treatment, 500 mg twice daily. Anorexia, generalized discomfort and itching after 3 weeks without fever, chills, rash, abdominal pain or joint pain. No patient had alcohol or other medication history. Symptoms were admitted to the hospital after 10 days and found scleral yellow dye, but no symptoms of chronic liver disease, liver, spleen without swelling, palpation of the right upper quadrant no tenderness. Laboratory tests: normal white blood cell count;