近年来有研究显示,含有异戊烯基结构的天然呫吨酮类化合物对多种肿瘤具有显著抑制活性,故而从此类化合物中寻找具有开发价值的抗肿瘤先导化合物,已成为一个研究热点。按来源分别介绍异戊烯基呫吨酮类天然化合物及其抗肿瘤活性研究新进展,并对其中部分化合物的作用机制及构效关系进行了初步探讨。 In recent years, some studies have shown that naturally-occurring xanthone compounds containing isopentenyl structures have significant inhibitory activities against many tumors. Therefore, finding promising antitumor lead compounds from such compounds has become a research hotspot. According to the sources, the new progress of the research on the natural compounds of isopentenylxanthones and their anti-tumor activities were introduced respectively. The mechanism of action and structure-activity relationship of some of these compounds were also discussed.