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目的分析全身热疗在非小细胞肺癌术后辅助治疗中的疗效。方法选取2008年1至9月在我院住院的ⅠB~ⅢA期非小细胞肺癌术后患者48例,随机分为观察组和对照组。观察组除放化疗常规辅助治疗外,于术后3周进行全身热疗1次。结果统计两组治疗后免疫学检测指标,其中K562杀伤比率、NK杀伤活性、T淋巴细胞比较差异有显著性(P<0.05),VEGF、B淋巴细胞及TI/Ts差异无显著性(P>0.05)。观察组2年复发3例,复发率为12.5%;对照组2年复发10例,复发率为41.7%,两组比较差异有显著性(P<0.05)。结论全身热疗能提高机体免疫力,抑制肿瘤转移,增强化放疗疗效,促进癌细胞凋亡。
Objective To analyze the curative effect of whole body hyperthermia in postoperative adjuvant therapy of non-small cell lung cancer. Methods Forty-eight patients with stage ⅠB-ⅢA non-small cell lung cancer admitted to our hospital from January to September in 2008 were randomly divided into observation group and control group. In addition to conventional radiotherapy and chemotherapy adjuvant treatment group, 3 weeks after the whole body hyperthermia 1. Results The immunological detection indexes of the two groups were statistically analyzed. K562 killing rate, NK killing activity and T lymphocyte were significantly different (P <0.05), while VEGF, B lymphocytes and TI / Ts had no significant difference (P> 0.05). In the observation group, 3 cases relapsed in 2 years, the recurrence rate was 12.5%. In the control group, 10 cases relapsed in 2 years and the recurrence rate was 41.7%. There was significant difference between the two groups (P <0.05). Conclusion Systemic hyperthermia can improve immunity, inhibit tumor metastasis, enhance the efficacy of chemoradiotherapy and promote apoptosis of cancer cells.