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目的：利用临床常用的生化指标，寻找可以预测山东省中老年回族人胰岛素抵抗（ IR）的替代标志物。方法本横断面研究共入选95名男性和104名女性中老年回族人。采集患者空腹血样检测血糖、胰岛素、肝酶和血脂水平。以稳态胰岛素评价指数（ HOMA-IR）评价人群IR状态，并以该指数的最高四分位数作为IR的切点，其数值为3．06。利用受试者工作特征曲线（ROC）的曲线下面积（AUC）评估潜在指标对IR的预测价值。结果在所有研究指标中，1/HDL-C比值和TG/HDL-C比值可以更好地预测人群的IR状态，其AUC值分别为0．720（95％CI：0．642～0．798）和0．710（95％CI：0．634～0．786）。1/HDL-C比值及TG/HDL-C比值预测IR的最佳切点分别为0．702（对应的HDL-C值为1．425 mmol/L，敏感性为69．4％，特异性为67．3％）和1．043（敏感性为65．3％，特异性为66．7％）。结论 HDL-C和TG/HDL-C比值可以用来预测山东省中老年回族人的IR状态。“,”Objective To find a surrogate marker to identify insulin resistance ( IR) in middle-aged and older Hui ethnic subjects in Shandong Province of China using biochemical indicators.Methods A total of 95 men and 104 women were included in the cross-sectional study.Fasting blood samples were collected to detect blood glucose, insulin, liver enzymes and lipid profiles.IR cut-off value was 3.06 as determined using the 75th percentile of HOMA-IR values.The areas under the curve ( AUC) of the receiver operating characteristic curves ( ROC) were used to compare the power of the potential markers.Results Compared with other biochemical indicators, 1/HDL-C ratio and TG/HDL-C ratio discriminated IR much better than others, with the values of AUC being 0.720 (95% CI:0.642-0.798) and 0.710(95% CI:0.634-0.786),respectively.The optimal cut-off points to identify IR were 0.702 (sensitivity 69.4%, specificity 67.3%) for 1/HDL-C ratio (1.425 mmol/L for HDL-C) and 1.043 ( sensitivity 65.3%, specificity 66.7%) for TG/HDL-C ratio. Conclusion HDL-C and TG/HDL-C ratio can easily identify IR in the urban middle-aged and older Hui ethnic popula-tion in Shandong Province.