Inhibition of proteasome by bortezomib increase chemosensitivity of bcr/abl positive human k562 chro

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Chronic myeloid leukaemia (CML) results from a translocation between chromosomes 9 and 22 which generates the BCR/ABL fusion oncopro-tein. BCR/ABL has constitutively tyrosine kinase activity resulting in leukemogenesis. Imatinib, a competitive inhibitor o
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