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目的探讨染色体核型异常及Y染色体微缺失与男性不育的关系。方法利用染色体技术、PCR技术等对233例男性重度少精子、无精子不育患者进行外周血染色体分析及Y染色体微缺失检测。结果 233例男性少精子、无精子不育患者中常染色体结构异常10例,占35.71%:性染色体数目异常18例,占64.29%。Y染色体微缺失11例,缺失率为4.72%。其中3人同时存在色体核型异常及Y染色体微缺失。结论男性少精子、无精子与染色体核型异常及Y染色体微缺失关系密切,对男性少精子、无精子不育患者进行染色体核型及Y染色体微缺失检测非常重要。
Objective To investigate the relationship between karyotype abnormality and Y chromosome microdeletions and male infertility. Methods Chromosome analysis and PCR technique were used to detect chromosomal analysis and Y chromosome microdeletion in 233 male patients with severe oligospermia and without sperm infertility. Results There were 10 cases of autosomal abnormalities in 233 cases of male oligospermatism without azoospermia, accounting for 35.71%. There were 18 cases of abnormal sex chromosomes, accounting for 64.29%. 11 cases of Y chromosome microdeletions, the deletion rate was 4.72%. Three of them had both chromosomal abnormalities and Y chromosome microdeletion. Conclusions Male oligospermia, azoospermia and chromosomal karyotype are closely related to Y chromosome microdeletions. It is very important to detect karyotype and Y chromosome microdeletion in male patients with oligospermia and azoospermia.