静脉输入大剂量的青霉素G(总量超过200百万单位)会产生药物过敏。即在下列情况下也会发生:①溶液在4℃下贮存4～24小时,并在短时间内输入。②使用新鲜配制,在6～24小时输入。过敏反应呈现淋巴细胞转化试验阳性及产生特异性IgG抗体,不产生IgE抗体。无明显变态反应发生。青霉素有很强的抗原性,溶液中青霉素不稳定,在室温升高和pH下降时衰败。它的降解产物和转化产物比青霉素G本身的抗原性更强。本文选择了三个试验组:A组和B组都患有细菌引起的炎症,注射的总剂量大致相近,只是注射的方 Intravenous administration of large doses of penicillin G (in excess of 200 million units) can cause drug allergy. That is, it happens under the following conditions: ① The solution is stored at 4 ℃ for 4 ~ 24 hours and input in a short time. ② use freshly prepared, in 6 to 24 hours input. Allergic reactions showed positive lymphocyte transformation test and produce specific IgG antibodies, do not produce IgE antibodies. No obvious allergic reaction occurred. Penicillin has a strong antigenicity, penicillin solution instability, decline at room temperature and pH decline. Its degradation products and transformation products are more antigenic than penicillin G itself. Three experimental groups were chosen for this study: Group A and Group B both had bacterial-induced inflammation with a total dose that was approximately the same