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C-反应蛋白(C-reactive protein,CRP)是一种含量极微的血清蛋白,但当炎症及组织坏死时可成千倍地增加。它由五个相同的非共价键连接的亚单位相成,每个亚单位的分子量为21,000道尔顿,排列呈环形对称。CRP与单核类细胞结合需要与多价配体[如肺炎球菌C多糖(CPS)或磷酸胆碱(PC)]形成复合物,或加热修饰.本研究组发现,这种复合的CRP可以结合3.0％左右的正常人淋巴细胞,双标记研究表明,这种淋巴细胞也表达IgG-FcR反应性.CRP还可在外周血中百分之几
C-reactive protein (CRP) is a minimal serum protein that can increase thousands of fold as inflammation and tissue become necrotic. It consists of five identical non-covalently linked subunits, each with a molecular weight of 21,000 daltons arranged in a ring-symmetric fashion. Binding of CRP to mononuclear cells requires the formation of a complex with a multivalent ligand, such as pneumococcal C polysaccharide (CPS) or phosphocholine (PC), or heat modification, and the group found that this complexed CRP could bind About 3.0% of normal human lymphocytes, double labeling studies have shown that this lymphocyte also express IgG-FcR reactivity .CRP can also be a percentage of peripheral blood