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本文采用绵羊红细胞(SRBC)经腹腔注入C_(57)BL小鼠作为免疫反应模型,观察小鼠在免疫反应中脾脏细胞糖皮质激素受体(GCR)数的变化,发现自SRBC致敏后第五天始小鼠脾脏细胞GCR数明显高于对照组(P<0.005),第七天达高峰,第十一天恢复至正常水平。地塞米松对致敏组和对照组小鼠脾脏细胞由PHA诱导的淋巴细胞转化抑制程度的明显差异可能与脾脏细胞GCR数变化有关。本文还用上述方法研究了妊娠小鼠,发现妊娠小鼠脾脏细胞GCR数明显高于未妊娠小鼠(P<0.05),这在调节母胎免疫反应中具有重要意义。
In this study, C57BL mice were injected intraperitoneally with sheep erythrocytes (SRBC) as an immune response model to observe the changes of glucocorticoid receptor (GCR) in spleen cells in immune response. It was found that after SRBC sensitized The number of GCR of spleen cells in the five-day-old mice was significantly higher than that in the control group (P <0.005), reaching the peak on the seventh day and returning to the normal level on the eleventh day. Dexamethasone sensitized group and control group of spleen cells PHA-induced lymphocyte transformation significantly inhibited the degree of GCR may be related to changes in spleen cells. This study also used the above method to study pregnant mice and found that the number of GCRs in spleen cells of pregnant mice was significantly higher than that of non-pregnant mice (P <0.05), which plays an important role in the regulation of maternal immune response.