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目的探讨盐酸帕罗西汀治疗功能性消化不良(FD)疗效。方法97例患者均为我院2006年11月～2009年6月门诊病例,经抑郁自评量表(SDS)、焦虑自评量表(SAS)测定,分为抑郁焦虑组45例与单纯FD组52例,均用盐酸帕罗西汀片(赛乐特)20mg,每天早晨口服一次,记录疗效与副作用。结果抑郁焦虑组总有效率91.1%,单纯FD组总有效率84.6%,两组间无显著差异(P=0.418),总有效率87.6%,头晕、口干等副作用发生率14.4%。结论FD发病与精神因素关系密切,短期应用盐酸帕罗西汀治疗FD疗效肯定,耐受性可。
Objective To investigate the efficacy of paroxetine hydrochloride in the treatment of functional dyspepsia (FD). Methods Ninety-seven patients were all outpatients from November 2006 to June 2009 in our hospital. SDS and SAS were used to evaluate the clinical outcomes of depression and anxiety in 45 patients and FD Group 52 cases, both with paroxetine hydrochloride tablets (Salbutamol) 20mg, taken orally once every morning to record the efficacy and side effects. Results The total effective rate was 91.1% in depression and anxiety group and 84.6% in simple FD group. There was no significant difference between the two groups (P = 0.418). The total effective rate was 87.6%. The incidence of side effects such as dizziness and dry mouth was 14.4%. Conclusion The incidence of FD is closely related to the psychological factors. Short-term use of Paroxetine Hydrochloride in the treatment of FD has definite curative effect and tolerability.