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目的观察抗氧化剂治疗对角膜组织中胶原酶活性的影响。方法以细菌性角膜溃疡为模型，测定不同抗氧化剂治疗后角膜组织中丙二酰二醛（ｍａｌｏｎｄｉａｌｄｅｈｙｄｅ，ＭＤＡ）含量和胶原酶活性。结果抗氧化剂联合抗菌素治疗较单用抗菌素能更有效地减少组织脂质过氧化和活性胶原酶生成。结论从动物实验角度证明了抗氧化剂治疗对胶原酶活化的影响，并提示抗氧化剂是一种理想的辅助用药，而且应联合用药。
Objective To observe the effect of antioxidants on the activity of collagenase in corneal tissue. Methods Bacterial corneal ulcer was used as a model to measure the content of malondialdehyde (MDA) and the activity of collagenase in corneal tissue after different antioxidants. Results Antioxidant combined with antibiotic treatment more effectively reduced lipid peroxidation and active collagenase production than single antibiotic. Conclusion From the animal experiment point of view, the effect of antioxidant therapy on the activation of collagenase is proved, and the antioxidant is an ideal auxiliary medicine, and should be combined.