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以 (5 - F3 ) -胸腺嘧啶核苷 (Td R)为前体 ,采用 Pd O/ Ba SO4 为催化剂 ,在 2 .5 mo L/ L KOH水溶液中进行催化卤氚取代反应。获得的标记物比活度为 9.1TBq/ g,与目前所用方法制备的标记物比活度 3TBq/ g相比提高 2倍。标记物放化纯度 >95 % ,示踪灵敏度可提高 70 %以上
(5 - F3) - thymidine (TdR) was used as precursor to catalyze the halogenated tritium substitution reaction in 2.5 mol L / L KOH aqueous solution using Pd O / Ba SO4 as catalyst. The specific activity of the obtained marker was 9.1TBq / g, which is double that of the 3TBq / g specific activity of the marker prepared by the current method. Marker radiochemical purity> 95%, traceability can be increased by more than 70%