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目的观察老年糖尿病患者长期服用二甲双胍的安全性及疗效。方法选取老年T2DM患者持续口服或未服二甲双胍9年各18例,定期监测血糖、HbA1c和肝肾功能等。结果二甲双胍治疗(T)组第9年底HbA1c<7%者占77.78%,对照(C)组为50%,两组比较差异有统计学意义(P<0.05)。两组肝肾功能及体重差异无统计学意义,肾小球滤过率均在正常范围内波动。结论老年T2DM患者长期服用二甲双胍具有良好的安全性和疗效。
Objective To observe the long-term safety and efficacy of metformin in elderly diabetic patients. Methods A total of 18 elderly patients with T2DM who received oral metformin or no metformin for 9 years were enrolled in this study. Blood glucose, HbA1c, liver and kidney function were regularly monitored. Results The metformin treatment group (T) had 77.78% of patients with HbA1c <7% and 50% of the control group (C) (P <0.05). There was no significant difference in liver and kidney function and body weight between the two groups, glomerular filtration rate fluctuated within the normal range. Conclusion Long-term use of metformin in elderly patients with T2DM has good safety and efficacy.