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目的探讨血清基质金属蛋白酶-2(MMP-2)、血管内皮生长因子(VEGF)在2型糖尿病脑梗死患者脑组织损伤及修复过程中的作用。方法选取30名2型糖尿病脑梗死患者(DMCI组)、30名单纯脑梗死患者(CI组)、20名健康体检者作为对照组(C组)。其中DMCI组:男11名,女19名,60~80岁,平均71.2岁;CI组:男12名,女18名,60~80岁,平均70.3岁;C组:男9名,女11名,60~80岁,平均69.0岁。采用酶联免疫吸附法检测DM-CI组、CI组发病1、7d及对照组体检时血清中MMP-2、VEGF的含量。结果 DMCI组发病1、7d血清MMP-2水平均高于CI组和C组(P(0.05);发病1d血清VEGF水平与CI组比较差异无统计学意义(P(0.05),但显著高于C组(P(0.01);发病7d血清VEGF水平显著低于CI组(P(0.01),但显著高于C组(P(0.01)。DMCI组、CI组发病7d MMP-2、VEGF水平均显著高于发病1d(P(0.05)。DMCI组血清MMP-2水平与FBG、HbAlc含量呈显著正相关(r=0.829,P=0.000;r=0.855,P=0.000);血清VEGF水平与FBG、HbAlc含量呈显著负相关(r=-0.501,P=0.005;r=-0.528,P=0.003);血清MMP-2水平与VEGF水平呈显著负相关(r=-0.586,P=0.001)。结论 2型糖尿病脑梗死患者不同时间段血清MMP-2、VEGF水平与糖代谢异常有显著相关性,MMP-2、VEGF参与糖尿病脑梗死的病理生理过程。
Objective To investigate the role of serum matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF) in the brain injury and repair of type 2 diabetic patients with cerebral infarction. Methods Twenty patients with type 2 diabetes mellitus (DMCI), 30 patients with simple cerebral infarction (CI) and 20 healthy controls were selected as control group (group C). Among them, the DMCI group consisted of 11 males and 19 females, aged from 60 to 80 years old, with an average of 71.2 years. CI group consisted of 12 males and 18 females, aged 60 to 80 years old, with an average age of 70.3 years. Group C: 9 males and 11 females Name, 60 to 80 years old, average 69.0 years old. The serum levels of MMP-2 and VEGF in DM-CI group, CI group and control group were detected by enzyme-linked immunosorbent assay. Results The level of serum MMP-2 in the first day and the seventh day of the DMCI group were significantly higher than those in the CI group and the C group (P <0.05). There was no significant difference in serum VEGF level between the first day and the third day after onset of the disease (P <0.05) The serum level of VEGF in group C and C were significantly lower than that in group C (P <0.01), but significantly higher than that in group C (P <0.01) (P <0.05) .The serum level of MMP-2 in DMMCI group was positively correlated with FBG and HbAlc levels (r = 0.829, P = 0.000; r = 0.855, P = 0.000) (R = -0.501, P = 0.005; r = -0.528, P = 0.003). There was a significant negative correlation between serum MMP-2 and VEGF (r = -0.586, P = 0.001). Conclusions Serum levels of MMP-2 and VEGF at different time points in type 2 diabetes mellitus patients are significantly correlated with abnormal glucose metabolism. MMP-2 and VEGF are involved in the pathophysiological process of diabetic cerebral infarction.