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目的探讨子痫前期患者各项生化指标的变化和临床意义,分析子痫前期患者的妊娠结局。方法选取116例子痫前期患者孕妇为研究组和116例正常孕妇作为对照组。分别检测2组孕妇ALT、AST、GGT、AKP、CK、LDH、α-HBDH、TP、ALB、TBIL、DBIL、BUN、Scr、UA。结果 2组GGT活性和TBIL、DBIL、BUN水平差异无统计学意义(P>0.05)。与对照组相比,研究组患者血清ALT、AST、AKP、CK、LDH、α-HBDH活性和Scr、UA水平均明显升高,血清TP、ALB水平均明显降低,差异均有统计学意义(P<0.05)。研究组早产、产后出血、胎盘前置等不良妊娠结局的发生率高于对照组,差异有统计学意义(P<0.05)。结论与同期正常孕妇相比,子痫前期患者孕妇部分生化指标发生明显变化。因此应严密监测子痫前期患者各项生化指标的变化,并对其进行及时有效处理和治疗,以获得良好的妊娠结局。
Objective To explore the changes and clinical significance of various biochemical indexes in patients with preeclampsia and analyze the pregnancy outcome in patients with preeclampsia. Methods 116 pregnant women with preeclampsia were selected as the study group and 116 normal pregnant women as the control group. ALT, AST, GGT, AKP, CK, LDH, α-HBDH, TP, ALB, TBIL, DBIL, BUN, Scr and UA were detected in 2 pregnant women respectively. Results There was no significant difference in GGT activity, TBIL, DBIL and BUN between the two groups (P> 0.05). Compared with the control group, serum ALT, AST, AKP, CK, LDH, α-HBDH activity and Scr, UA levels in study group were significantly increased, serum TP and ALB levels were significantly lower, the difference was statistically significant P <0.05). The incidence of adverse pregnancy outcomes such as preterm birth, postpartum hemorrhage and placenta previa in the study group was significantly higher than that in the control group (P <0.05). Conclusion Compared with normal pregnant women in the same period, some biochemical indexes of pregnant women in preeclampsia changed obviously. Therefore, we should closely monitor the biochemical changes in patients with preeclampsia, and its timely and effective treatment and treatment in order to obtain a good pregnancy outcome.