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研究妊娠17～22周的9例孕妇,在含化硝苯啶10mg 前、后测量子宫动脉上升支收缩期与舒张期的血流速度比值(S/D 值);7例病人服安慰剂作对照。研究组的平均收缩压116mmHg,舌下含化硝苯啶10mg 后25min 降为106mmHg(p<0.01);而后血压在107～110mmHg 之间波动。对照组没有明显变化。研究组含化10mg 硝苯啶后,平均 S/D 值5min 时是2.85,最低到2.35(无显著性);20min 上升为2.66,35min 时再次降到2.37,后又逐渐上升,60min 时升到2.97;对照组没有这些变化。
Nine pregnant women at 17-22 weeks of gestation were studied for the ratio of blood flow velocity (S / D) to systolic and diastolic velocities of uterine artery before and after 10 mg nifedipine; 7 patients received placebo Control. The study group had an average systolic blood pressure of 116 mmHg and a sublingual 10 mg nifedipine reduced to 106 mmHg 25 min (p <0.01). Blood pressure then fluctuated between 107 and 110 mmHg. The control group did not change significantly. The study group containing 10mg nifedipine, the average S / D value of 5min was 2.85, the lowest to 2.35 (no significant); 20min rose to 2.66,35 min again dropped to 2.37, then gradually increased, rose to 60min 2.97; the control group did not have these changes.