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硝普钠(nitroprusside)是目前治疗高血压危象较为理想的药物,但由于它有非选择性扩张血管作用,可使肾功能减退并产生冠脉窃血的后果。而酚诺多巴(fenokiopam)靠激动全身血管和肾脏血管的多巴胺-1受体,从而降低血压,改善肾功能。以前重点放在研究两药对血压和肾脏的影响,但忽视了对心功能效应的研究。本研究观察两药对左室收缩和舒张功能的放射性核素指数的影响。病人和方法从56例年龄在21～75岁和舒张压>120mmHg 的患者中,除去有下列禁忌症如舒张压>170mmHg、孕妇、嗜铬细胞瘤、慢
Nitroprusside is the ideal drug for the treatment of hypertensive crisis, but due to its non-selective dilation of blood vessels, renal function can be reduced and the consequences of coronary steal. Fenokiopam, on the other hand, activates dopamine-1 receptors in whole blood vessels and renal blood vessels, lowering blood pressure and improving renal function. Prior focus on the two drugs on blood pressure and kidney effects, but ignored the study of cardiac function. This study observed two drugs on left ventricular systolic and diastolic function of the radionuclide index. PATIENTS AND METHODS Fifty-six patients aged 21-75 years with diastolic blood pressure> 120 mmHg were excluded of contraindications such as diastolic blood pressure> 170 mmHg, pregnant women, pheochromocytoma,