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C/EBPα基因是抑癌基因,有抑制增殖、促进分化和调节DNA损伤反应等作用。各种机制如对抗性的蛋白质-蛋白质相互作用、基因突变和翻译后修饰等导致C/EBPα转录抑制或活性丧失,可能诱发肿瘤。本文结合国内外研究现状,介绍C/EBPα基因的结构、功能及与肿瘤的诊断、治疗和预后的关系。
C / EBPα gene is tumor suppressor gene, inhibit proliferation, promote differentiation and regulate DNA damage response and so on. Various mechanisms such as antagonistic protein - protein interactions, gene mutations and posttranslational modifications lead to C / EBPα transcription inhibition or loss of activity, may induce tumors. In this paper, the current status of research at home and abroad, C / EBPα gene structure, function and tumor diagnosis, treatment and prognosis.