p53基因是一种广谱的肿瘤抑制基因,其产物p53为一多功能的转录调节因子,可以发挥调节细胞生长、细胞凋亡和DNA修复的作用。在人类肿瘤已发现多种p53基因的点突变,但突变并不是p53蛋白质丧失功能的唯一途径。胞内蛋白可能影响其活性和功能。53BP1和53BP2是p53在胞浆中的两种结合蛋白。本文阐述了有关这两种蛋白质的研究进展。 P53 gene is a broad-spectrum tumor suppressor gene, and its product p53 is a multifunctional transcriptional regulator that can regulate cell growth, apoptosis and DNA repair. A number of point mutations in the p53 gene have been found in human tumors, but mutations are not the only way for the p53 protein to lose its function. Intracellular proteins may affect their activity and function. 53BP1 and 53BP2 are two binding proteins of p53 in the cytoplasm. This article describes the research progress on these two proteins.